End To End Differentiable Protein Structure Prediction From Sequence

via “end-to-end differentiable protein structure prediction from sequence”

* 📰 2022: [ChatGPT: Optimizing Language Models For Dialogue (ChatGPT)](https://openai.com/blog/chatgpt/)

Unique: Uses a hybrid architecture combining MSA embeddings (capturing evolutionary information) with pairwise distance and angle predictions in a single differentiable model, trained on ~170k PDB structures. Achieves CASP14 accuracy (GDT_TS ~87%) without requiring template-based homology modeling, a paradigm shift from traditional physics-based or template-dependent methods.